I still find it funnier then Seinfeld. Could never understnad the Seinfeld love, it just doesnt make laugh. I find Curb your enthusiasm and even Louie to being superior, but hey what do I know.
I agree The Simpsons greatest comedy of all time.
I can't really compare dramas to comedies. And I haven't seen all of a few well rated ones to make final judgements (sopranos, 6fu).
Having said that I think breaking bad at it's best is the best drama I have seen. But The Wire is more consistent so overall rate that a little higher (could change if s5 of bb is amazing)
Edit- Yes as to the above bb is alot better than those two shows. SoA has some awesome moments, but the writing is a long way behind bb. Supernatural from what I have seen is another couple of rungs below soa.