Don't be misled: AOD9604 is definitely a performance-enhancing drug

[jenny61_99]

AOD has GRAS (generally recognized as safe) status in the US, so lets not get carried away with the safety angle.

Self affirmed, not FDA approved. There is a difference.

 

[Sydney Bloods]

But that is how many of these so called football supporters are veiling their delight at our predicament.

Hiding behind the safety of players argument online while praying beside their beds each night for us to be crushed into insignificance.

Notice the huge number of "concerned with the health of the players" Carlton supporters frequent these threads...

It's less to do with the health of the players themselves, more to do with the fact your club it's administration and supporters don't seem to give two shits about it.

It's not just aod that was taken, there's many drugs were administered by your club, your club has gone on record as saying they aren't sure what was given to your players.

And none of you bat an eye lid, that's ok in your book. It's like you don't actually give a damn about the players at all.

 

[Magruder]

But that is how many of these so called football supporters are veiling their delight at our predicament.

Hiding behind the safety of players argument online while praying beside their beds each night for us to be crushed into insignificance.

Notice the huge number of "concerned with the health of the players" Carlton supporters frequent these threads...

I glad you understand that the footballing public considers the EFC's conduct to be appalling.

 

[AFLQLD]

What if you went above and beyond the process prescribed by the sport's governing body to determine substance status?
What if you were given misleading advice by the experts who you were directed to for guidance?
What if ASADA provided the wrong advice at the time?
What if it can be successfully argued that AOD is not a PED?
What if it can be successfully argued that AOD is outside the SO catch all?

Would you still trash someone's career & reputation?

What if you had a letter to prove all of this?

Would your club have, through its very own incompetence, trashed its own reputation and those of its players if it had a copy of a letter?

 

[DudleyB]

What if the lochness monster was in the maribynong?

It is strict liability .

So let me try and follow the line of argument you numpties are following

1 . Asada wrote an email to dank green lighting aod.
2. Bombers took a truckload of it even though its not performance enhancing .

Are they really the arguments you are pushing ? Seriously ?
Take a big deep breath if that is your argument .
Seriously embarrassing .

 

[bad setanta]

But that is how many of these so called football supporters are veiling their delight at our predicament.

Hiding behind the safety of players argument online while praying beside their beds each night for us to be crushed into insignificance.

Notice the huge number of "concerned with the health of the players" Carlton supporters frequent these threads...

Not only are we concerned about the health of the essendon players we are also concerned about the mental health of most of the essendon supporters.

 

[sherb]

Not only are we concerned about the health of the essendon players we are also concerned about the mental health of most of the essendon supporters.

It's nice that some here are displaying concern for the welfare of the Essendon players.

It's just a sad indictment on the Bombers supporters that they aren't the ones doing it.

 

[DudleyB]

https://peptidesdirect.com.au/AOD9604

http://www.abc.net.au/dimensions/dimensions_health/Transcripts/s786811.htm

 

[Ancient Tiger]

Conditional GRAS to be exact, but well tested on humans it seems:

Metabolic Pharmaceuticals Pty Ltd (Metabolic)

Metabolic is seeking to derive value from the Company’s past investment of over $50 million in the pharmaceutical development of AOD9604. The peptide has proven to be safe and well tolerated in a total of 6 human clinical trials involving 925 humans.
Potential means of deriving value from AOD9604 currently being actively pursued include seeking partners and licensing interest for the use of AOD9604 in:
(i) Over the counter (OTC) products in the United States for fat reduction under a self-affirmed GRAS status.

Metabolic has recently achieved a self-affirmed GRAS (Generally Recognised As Safe) status (conditional on a journal publication of existing safety data) which allows the marketing of AOD9604 into the US market. This means that AOD9604 can be legally added to foods, drinks, nutraceuticals & dietary supplements.

AOD would be useless as an additive to orally ingested products. As a peptide it will be broken down in the the alimentary tract. For efficacious use it must be injected. Otherwise insulin would be able to be eaten and being a type 1 diabetic wouldn't have the hassles it has now.
If his was how it was tested, no wonder it was safe! It wouldn't even get into the system!

 

[Lance Uppercut]

Australia (as usual) is having the debate Europe and Nth America had 20 years ago.

You Bombers fans and all the parasites and vultures trying to earn a buck from this (PR lackys and Lawyers) attempts to find loopholes in the wada code and find ways to cover up cheating is so embarrassing.

Do you Bombers numpties think all these arguments haven't been run umpteen times in Europe and Nth America?

Read my lips:

No ifs no buts - if you take a banned substance you are done (unless it was injected in you while you were unconscious).

and yet, admissions made, no infractions handed out.

Not quite sure your lips are talking that much sense

 

[mxett]

https://peptidesdirect.com.au/AOD9604

http://www.abc.net.au/dimensions/dimensions_health/Transcripts/s786811.htm

Surely you're not posting these as evidence

 

[Lance Uppercut]

So let me try and follow the line of argument you numpties are following

Seriously embarrassing .

are you incapable of discussing the issue without resorting to name calling?

 

[mxett]

AOD would be useless as an additive to orally ingested products. As a peptide it will be broken down in the the alimentary tract. For efficacious use it must be injected. Otherwise insulin would be able to be eaten and being a type 1 diabetic wouldn't have the hassles it has now.
If his was how it was tested, no wonder it was safe! It wouldn't even get into the system!

Can you explain why it underwent numerous oral trials then? How did they have the information to fail it for efficacy if their very method of administration was flawedd?

 

[RU486]

AOD would be useless as an additive to orally ingested products. As a peptide it will be broken down in the the alimentary tract. For efficacious use it must be injected. Otherwise insulin would be able to be eaten and being a type 1 diabetic wouldn't have the hassles it has now.
If his was how it was tested, no wonder it was safe! It wouldn't even get into the system!

Metabolic Pharmaceuticals reported the successful completion of its phase IIA human clinical trial of obesity drug AOD9604 by single- dose oral administration, showing positive results.

"This landmark result is the company's most important milestone achieved to date. Oral administration, the preferred mode of drug delivery, will maximize the commercial potential of AOD9604," said Chris Belyea, managing director.

"In all the trials performed so far, AOD9604 has consistently shown that humans respond to AOD9604 with increased fat metabolism, without side effects having been seen. This latest result provides key evidence that the oral activity shown in animals also applies to humans. We look forward with anticipation to forthcoming trials and our expectation is that AOD9604 will safely produce a meaningful weight reduction after daily oral dosing."

Increased average fat breakdown compared with placebo was observed at all dose levels of AOD9604 (9, 27 and 54 mg) lasting several hours after administration, reaching statistical significance at 27 mg. Fat breakdown, a signal of drug activity, is followed in the blood by measuring levels of nonesterified fatty acids (NEFA). NEFA is a marker, evident after a single dose, of fat metabolic changes that are expected to result in weight loss after extended daily dosing.

Preparations are now underway for a safety study, dosing once- daily for 1 week, to be conducted before year end in preparation for an extensive weight reduction study for 2003.

Metabolic's candidate obesity drug, AOD9604, invented at Monash University, acts specifically on the body's fat cells to enhance the breakdown of stored fats and inhibit the synthesis of new fat. This result is biochemically similar to the slimming effects of physical exercise. AOD9604 has proven to be effective in reducing obesity in laboratory animals through once daily oral administration, with no effect on food intake.

The drug is modeled on the active fat reducing portion of the human growth hormone (hGH) molecule. hGH occurs naturally in the body and is involved in promoting growth. In addition it has pronounced effects on body fat. Scientists at Monash University have shown that, when dosed to animals, AOD9604 has the fat- reducing effects of the intact growth hormone without its other unwanted effects having been observed.

This article was prepared by Obesity, Fitness & Wellness Week editors from staff and other reports.

 

[Snake_Baker]

Metabolic's candidate obesity drug, AOD9604, invented at Monash University, acts specifically on the body's fat cells to enhance the breakdown of stored fats and inhibit the synthesis of new fat. This result is biochemically similar to the slimming effects of physical exercise.

Why would a bunch of admittedly underdeveloped AFL footballers need this?

Was AOD utilised as a masking agent?

 

[RU486]

Why would a bunch of admittedly underdeveloped AFL footballers need this?

Was AOD utilised as a masking agent?

I have come to the conclusion that AOD was used in order to reduce bodyfat whilst maintaining muscular strength, thus fitness levels improved without compromising strength.

 

[Snake_Baker]

I have come to the conclusion that AOD was used in order to reduce bodyfat whilst maintaining muscular strength, thus fitness levels improved without compromising strength.

How did you arrive at this conclusion? Were they on a gorging diet as part of their development?

 

[Ancient Tiger]

Can you explain why it underwent numerous oral trials then? How did they have the information to fail it for efficacy if their very method of administration was flawedd?

These trials are yet to be published in peer reviewed journals so I would not believe anything a company that has invested millions in this drug publishes. Sorry.

Oral ingestion of a small peptide does not make sense.

Even if this was the preferred route, why were the Essendon players subjected to multiple injections?

You cannot argue that it is most efficacious by oral admin and then support the injection of unknown and untested quantities into humans. Where are the trials on injecting humans?

Please answer these questions.

 

[mxett]

@ProfDocHealth: @Buckets74 @MitchellGlenn 6month outcome trial result was clear & negative. Nothing equivocal. By design AOD9604 not anabolic

 

[mxett]

These trials are yet to be published in peer reviewed journals so I would not believe anything a company that has invested millions in this drug publishes. Sorry.

Oral ingestion of a small peptide does not make sense.

Even if this was the preferred route, why were the Essendon players subjected to multiple injections?

You cannot argue that it is most efficacious by oral admin and then support the injection of unknown and untested quantities into humans. Where are the trials on injecting humans?

Please answer these questions.

I'm not sure if they haven't been published but theyve certainly been summarised and they show AOD failed in efficacy as a fat burner and was never even designed to build muscle and hasnt been shown to either.

Why spend millions on a drug and not administer it in trials properly?

 

[RU486]

How did you arrive at this conclusion? Were they on a gorging diet as part of their development?

It is well known that Essendon embarked upon a strength based training regime, with such a regime players needed to increase caloric surplus to gain muscle. Increased fat metabolism is a proven outcome of AOD treatment, thus players were able to increase muscle mass without the associated gains in bodyfat.

 

[Gigantor]

Burns abdominal fat hey?

Does anyone know where I can get this drug from?

It's umm...not for me....it's for a mate.

Yes.

You can order these fat burning concoctions from the back of comic books and other high-brow publications.


And it really works. Honestly, a comic book would not lie about such a thing - it really, really works.

 

[Snake_Baker]

It is well known that Essendon embarked upon a strength based training regime, with such a regime players needed to increase caloric surplus to gain muscle. Increased fat metabolism is a proven outcome of AOD treatment, thus players were able to increase muscle mass without the associated gains in bodyfat.

Come again?

Were they on a power lifting program?

 

[Ancient Tiger]

I'm not sure if they haven't been published but theyve certainly been summarised and they show AOD failed in efficacy as a fat burner and was never even designed to build muscle and hasnt been shown to either.

Why spend millions on a drug and not administer it in trials properly?

I have performed a medline search and there are no published trials.
The reason to advocate its use orally is that these companies are all about profit. The profit they could make with a pill is about 1,000,000 times greater than an injection. Think about it.

You still haven't explained why they injected it into Essendon players if it has been tested orally!

 

[RU486]

These trials are yet to be published in peer reviewed journals so I would not believe anything a company that has invested millions in this drug publishes. Sorry.

Oral ingestion of a small peptide does not make sense.

Even if this was the preferred route, why were the Essendon players subjected to multiple injections?

You cannot argue that it is most efficacious by oral admin and then support the injection of unknown and untested quantities into humans. Where are the trials on injecting humans?

Please answer these questions.

It is orally bioactive: