Not a fan of the 4 NSQ/Qld games personally. It likely means back-to-back travel at some other point of the season. Which is generally best avoided, particularly for Qld and WA sides who generally travel further each trip (I guess the exception being between SEQ and Sydney).
And Thursday is bad enough, Wednesday can **** right off.
The season opened on a Wednesday in 2022 with the Grand Final rematch between the Bulldogs and Melbourne. It worked well, as you'd expect. You can utilize Wednesday in Round 1, in a way you can't in other rounds because of 4-5 day breaks, which are not an issue in round one, because there is no match the previous week. It spreads the games out, is better for TV and it's really the only round you can do it.
There shouldn't be back to back travel (in theory) for the Qld/NSW sides because there is the local derby.
For example if you play out this scenario:
home
away
away - local derby
away
home
Technically there is three away games in a row, but in reality, for travel it is H-A-H-A-H